Skin-cells-turned-to-heart-cells help unravel genetic underpinnings of cardiac function

A small genetic study identified a protein linked to many genetic variants that affect heart function. Researchers are expanding the model to other organ systems and at larger scales to create a broader understanding of genes and proteins involved.

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New findings enable more heart donations

There is a risk of every fourth heart examined for possible donation being dismissed as unusable due to stress-induced heart failure. But this condition, according to new research, has no bearing on the outcome of a transplant. These results open the way for up to 30% more heart transplant.

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Mystery underlying heart toxicity caused by diabetes drugs solved

For new diabetes medications, in which one drug aims to address the excess of lipids and glucose in the blood, the therapeutic benefits, while great, frequently are accompanied by dangerous toxic effects to the heart. Why and how these drugs cause heart dysfunction in diabetes patients has been unclear. Now, scientists show that certain diabetes drugs have a profound toxic effect on the generation and function of mitochondria.

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US pediatric heart transplant waitlist policy change falls short of intended benefits

In March 2016, the Organ Procurement and Transplantation Network revised its criteria for prioritizing children awaiting heart transplantation in the US with the intention of reducing the number of deaths on the waitlist, but a new study suggests unintended consequences.

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Potential target for cardiac fibrosis treatment

A research team has identified a potential target for treating heart failure related to fibrosis. The study looked at an epigenetic 'reader' protein known as BRD4, showing that it serves a central role in regulating the activation of cardiac fibroblasts. They also found that chemical inhibitors of BRD4 potently block cardiac fibroblast activation.

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