Using anew method called Net-CAGE, researchers identified as many as 20,000 new enhancers in humans. They found that while promoters are activated in a variety of cell types, enhancers tend to function in just 1 cell type, thus showing an important difference between the 2 types of region.
Read moreThe cells of our immune system constantly communicate with one another by exchanging complex protein molecules. A team has now revealed how dedicated cellular control proteins, referred to as chaperones, detect immature immune signaling proteins and prevent them from leaving the cell.
Read moreInsulin-like growth factor 1 (IGF1) is essential for allowing tendons to adapt to physical activity and grow properly, according to basic science research. The findings provide a strong rationale for pursuing clinical trials to explore IGF1 as a new target for treating tendon injuries in humans.
Read moreIn experiments with mice, researchers have shown they can harness the power of iNKT cells to attack tumor cells and treat cancer. The new method suppressed the growth of multiple types of human tumors that had been transplanted into the animals.
Read moreA new platform brings together CRISPR genome editing with magnetic cell sorting to reveal new drug targets for cancer and regenerative medicine.
Read moreIn a proof-of-concept study, researchers have shown that exosomes harvested from human skin cells are more effective at repairing sun-damaged skin cells in mice than popular retinol or stem cell-based treatments currently in use. Additionally, the nanometer-sized exosomes can be delivered to the target cells via needle-free injections.
Read moreResearchers reported today that bone marrow cells used to treat ischemic stroke in an expanded Phase I trial were not only safe and feasible, but also resulted in enhanced recovery compared to a matched historical control group.
Read moreScientists have designed a new method for post-operative wound closing and healing that is both fast and effective. This strategy revolves around engineered 'cell sheets' — or layers of skin-based cells. The procedure culminates in a wound dressing that is custom made for a specific cut or lesion that can be used to effectively treat open skin areas after surgeries. The findings were published in Scientific Reports on July 18th.
Read moreScientists have constructed synthetic vesicles in which ATP, the main energy carrier in living cells, is produced. The vesicles use the ATP to maintain their volume and their ionic strength homeostasis. This metabolic network will eventually be used in the creation of synthetic cells – but it can already be used to study ATP-dependent processes.
Read moreIn a small safety and feasibility clinical trial, researchers have demonstrated for the first time that senescent cells can be removed from the body using drugs termed 'senolytics.' The result was verified not only in analysis of blood but also in changes in skin and fat tissue senescent cell abundance.
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