An age-related decline in recovery from muscle injury can be traced to a protein that suppresses the special ability of muscle stem cells to build new muscles, according to new work.
Read moreScientists have taken a major step to address the challenge of engineer tissues organized like native tissues. They have demonstrated a new method to fabricate scaffolds presenting spatially organized cues to control cell behavior locally within one material.
Read moreNew research found that oncogene SET/TAF1, which was found to be a proto-oncogene of acute myeloid leukemia (AML), contributes to proper chromosome partitioning as a tension sensor. Additionally, abnormal SET protein disrupts tension sensor system at the centromere, leading to missegregation of the chromosomes and thereby cancer. These findings may lead to a discovery for a new kind of leukemia treatment.
Read moreResearchers are developing a technique for imaging mammalian gene expression with ultrasound by combining human bacteria and virus DNA.
Read moreThe first cell atlas of the human kidney's immune system has been created after scientists mapped nearly 70,000 individual kidney cells from early life and adults. Researchers generated the atlas and used it to map immune cells in the kidney. This shows for the first time how the kidney's immune system develops during early life, and strengthens after birth and as we mature into adults, with implications for tackling kidney disease and transplant rejection.
Read moreA new imaging method follows young neurons in a developing embryo as they progress from a messy jumble of cells into a coordinated control center. The approach lets scientists track development and emerging cell function simultaneously across entire circuits.
Read moreScientists have discovered how temporal fluctuations in the levels of two transcription factors can push embryonic stems cells into becoming different cell types.
Read moreIntestinal epithelial cells (IECs) are exposed to diverse types of environmental stresses such as bacteria and toxins, but the mechanisms by which epithelial cells sense stress are not well understood. New research has found that Nox-ROS-ASK1-MKK3-p38 signaling in IECs integrates various stresses to facilitate intestinal regeneration.
Read moreThis major step forward in organoid development could sharply accelerate the concept of precision medicine and someday lead to transplantable tissues grown in labs.
Read moreIn the presence of some disruptive elements, cancer cells are unable to replicate its DNA optimally. While known to be linked to the increase in genetic mutations, the exact mechanism at work remained unknown until now. By deciphering how replication stress induces the loss or gain of whole chromosomes in the daughters of cancer cells, researchers provide new knowledge that will ultimately lead to better diagnosis and possibly better treatment of cancer.
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