Mesothelioma trial suggests immunotherapy as an alternative to chemotherapy

Patients with mesothelioma may gain similar benefit from immunotherapy as chemotherapy, and good responders may provide important clues to novel treatment for the thousands of new cases each year. New data highlight the need to understand the biological mechanisms whereby mesothelioma, which is incurable, adapts to immunotherapy in some patients but not in others, resulting in variations in treatment response.

Read more

First large-scale study of universal screening for autism raises questions about accuracy

In the first large, real-world study of universal screening for autism spectrum disorder (ASD) in toddlers, researchers have found that the most widely used and researched screening tool is less accurate than shown in previous studies conducted in research laboratory settings. The new study also revealed significant disparities in detecting early autism symptoms in minority, urban and low-income children.

Read more

Trial finds high-dose radiation effective for men whose prostate cancer has spread

A randomized clinical trial of targeted, high-dose radiation for men with oligometastatic prostate cancer has shown the treatment to be an effective and safe option for patients who wish to delay hormone-suppression therapy. The phase II trial found that radiation therapy can generate an immune system response not previously believed possible in this type of cancer.

Read more

Cancer: The origin of genetic mutations

In the presence of some disruptive elements, cancer cells are unable to replicate its DNA optimally. While known to be linked to the increase in genetic mutations, the exact mechanism at work remained unknown until now. By deciphering how replication stress induces the loss or gain of whole chromosomes in the daughters of cancer cells, researchers provide new knowledge that will ultimately lead to better diagnosis and possibly better treatment of cancer.

Read more