Using a new technique that can identify genetic profiles of individual cells, researchers modeled a breast cancer tumor's potential resistance to a drug, and then identified a drug combination that reversed that resistance.
Read moreFor new diabetes medications, in which one drug aims to address the excess of lipids and glucose in the blood, the therapeutic benefits, while great, frequently are accompanied by dangerous toxic effects to the heart. Why and how these drugs cause heart dysfunction in diabetes patients has been unclear. Now, scientists show that certain diabetes drugs have a profound toxic effect on the generation and function of mitochondria.
Read moreMichigan State University scientists have invented a new way to monitor chemotherapy concentrations, which is more effective in keeping patients' treatments within the crucial therapeutic window.
Read moreA unique new flexible and stretchable device, worn against the skin and capable of producing electrical energy by transforming the compounds present in sweat, was recently developed and patented. This cell is already capable of continuously lighting an LED, opening new avenues for the development of wearable electronics powered by autonomous and environmentally friendly biodevices.
Read moreScientists have developed a new class of antibiotic drug candidates which has high potential to be developed into a new generation of antibiotics fighting against multi-drug resistant superbugs including methicillin-resistant Staphylococcus aureus (MRSA).
Read moreScientists have succeeded in designing a compound to hook onto the pocket of the enzyme FTase and GGTase I, thereby inhibiting K-Ras. Scientists have worked to concoct an effective drug to target K-Ras proteins which cause cancer when they mutate. It is difficult to infiltrate K-Ras due to a lack of interactive pockets, so a strategy was devised to attack the necessary enzyme in the lipid modification of K-Ras.
Read moreOne of the WHO's 3 critical priority pathogens, Acinetobacter baumannii, for which new antibiotics are urgently needed is one step closer to being tackled, as researchers have made a breakthrough in understanding the enzymes that assemble the antibiotic enacyloxin.
Read moreAccording to a new study the distribution of drug molecules within the brain can be improved by utilizing LAT1, which is expressed highly in the brain.
Read moreReleasing drugs that are packaged into microcapsules requires a significant amount of force, and the resulting burst can cause damage to human tissues or cause blood clots. A new technique creates lopsided microcapsule 'shells' that can burst and release their cargo at much lower pressure, making them safer for use in the body.
Read moreNew approach to producing indolent scaffolds could streamline development and production of small-molecule pharmaceuticals, which comprise the majority of medicines in use today.
Read more