More efficient drug delivery within the brain by utilizing LAT1
According to a new study the distribution of drug molecules within the brain can be improved by utilizing LAT1, which is expressed highly in the brain.
Read morePharmacology
Thinner shells for delivering gentler therapeutic bursts
Releasing drugs that are packaged into microcapsules requires a significant amount of force, and the resulting burst can cause damage to human tissues or cause blood clots. A new technique creates lopsided microcapsule 'shells' that can burst and release their cargo at much lower pressure, making them safer for use in the body.
Read moreNew reaction will make indoline scaffolds available for pharmaceutical development
New approach to producing indolent scaffolds could streamline development and production of small-molecule pharmaceuticals, which comprise the majority of medicines in use today.
Read moreDo the costs of cancer drugs receive enough attention?
A recent analysis from Canada found that information on health-related quality of life is often not collected for investigational cancer drugs or used to calculate the balance of costs and benefits of these drugs when they are submitted for reimbursement.
Read moreLong-acting injectable multi-drug implant shows promise for HIV prevention and treatment
UNC researchers have created an injectable multi-drug delivery system that is removable, biodegradable and effective for up to a year in some cases. The author says the ability to administer multiple drugs with this implant is an important advancement in this research.
Read moreSalmonella causing bloodstream infections in central Africa resistant to nearly all drugs
The first extensively drug-resistant (XDR) strains of Salmonella Typhimurium, a pathogen which is responsible for millions of bloodstream infections per year in sub-Saharan Africa, have been identified in the Democratic Republic of Congo (DRC). Drug-resistance has increased in successive groups of S. Typhimurium over time. These new strains are resistant to all but one of the commonly available drugs in the DRC, with one sample showing reduced susceptibility to this final antibiotic.
Read moreInnovative candidate drug against malaria
A molecule once designed to cure the skin disease psoriasis appears to be particularly effective against malaria. The antimalarial properties were revealed thanks to one researcher's inspired hunch when the psoriasis drug discovery program came to a dead end. The candidate drug offers considerable potential for combating this infectious disease.
Read moreMedications underused in treating opioid addiction
Though research shows that medication-assisted treatment can help people who are addicted to opioids, the three drugs approved by the Food and Drug Administration (FDA) are underused, according to a review of current medical data on opioid addiction in the U.S.
Read moreEvidence underpinning approval of new cancer drugs raises questions
Around half of trials that supported new cancer drug approvals in Europe between 2014 and 2016 were judged to be at high risk of bias, which indicates that treatment effects might have been exaggerated, concludes a new study.
Read moreNew tool in fight against malaria
Modifying a class of molecules originally developed to treat the skin disease psoriasis could lead to a new malaria drug that is effective against malaria parasites resistant to currently available drugs.
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