Using a new technique that can identify genetic profiles of individual cells, researchers modeled a breast cancer tumor's potential resistance to a drug, and then identified a drug combination that reversed that resistance.
Read moreNew research has resulted in a reactive copper-nitrene catalyst that pries apart carbon-hydrogen (C-H) bonds and transforms them into carbon-nitrogen (C-N) bonds, which are a crucial building block for chemical synthesis, especially in pharmaceutical manufacturing.
Read moreScientists have developed a new class of antibiotic drug candidates which has high potential to be developed into a new generation of antibiotics fighting against multi-drug resistant superbugs including methicillin-resistant Staphylococcus aureus (MRSA).
Read moreScientists have succeeded in designing a compound to hook onto the pocket of the enzyme FTase and GGTase I, thereby inhibiting K-Ras. Scientists have worked to concoct an effective drug to target K-Ras proteins which cause cancer when they mutate. It is difficult to infiltrate K-Ras due to a lack of interactive pockets, so a strategy was devised to attack the necessary enzyme in the lipid modification of K-Ras.
Read moreOne of the WHO's 3 critical priority pathogens, Acinetobacter baumannii, for which new antibiotics are urgently needed is one step closer to being tackled, as researchers have made a breakthrough in understanding the enzymes that assemble the antibiotic enacyloxin.
Read moreAccording to a new study the distribution of drug molecules within the brain can be improved by utilizing LAT1, which is expressed highly in the brain.
Read moreResearchers have found a way to track the formation of soluble amyloid beta peptide aggregates in lab samples. The aggregates are implicated in the onset of Alzheimer's disease.
Read moreNew approach to producing indolent scaffolds could streamline development and production of small-molecule pharmaceuticals, which comprise the majority of medicines in use today.
Read moreA recent analysis from Canada found that information on health-related quality of life is often not collected for investigational cancer drugs or used to calculate the balance of costs and benefits of these drugs when they are submitted for reimbursement.
Read moreUNC researchers have created an injectable multi-drug delivery system that is removable, biodegradable and effective for up to a year in some cases. The author says the ability to administer multiple drugs with this implant is an important advancement in this research.
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