Diabetes: A next-generation therapy soon available?

Insulin is normally produced by pancreatic beta cells. In many people with diabetes, pancreatic cells are not functional, causing a chronic and potentially fatal insulin deficiency that can only be controlled through daily insulin injections. However, this approach has serious adverse effects. In order to improve therapy, researchers have identified a protein called S100A9 which seems to act as a blood sugar and lipid regulator while avoiding the most harmful side effects of insulin.

Read more

New human reference genome resources help capture global genetic diversity

Scientists have assembled a set of genetic sequences that enable the reference genome to better reflect global genetic diversity. The new sequences improve the utility of the human reference genome, a touchstone resource for modern genetics and genomics research.

Read more

Sequencing African genomes yields new data resource with broad applicability

By collaborating globally in a new, large-scale effort, researchers have made strong progress in sequencing genomes from regions and countries across Africa. These findings will enable more broadly representative and relevant studies ranging from basic through clinical genetics.

Read more

New insights into biological underpinnings of schizophrenia

Researchers have implicated 10 new genes in the development of schizophrenia using a method called whole exome sequencing, the analysis of the portion of DNA that codes for proteins. A global consortium of schizophrenia research teams incorporated genetic data from over 125,000 people to gain deeper insights into the genetic underpinnings of schizophrenia.

Read more

New genetic-based epilepsy risk scores

An international team of researchers has developed new genetic-based epilepsy risk scores which may lay the foundation for a more personalized method of epilepsy diagnosis and treatment. This analysis is the largest study of epilepsy genetics to date, as well as the largest study of epilepsy using human samples.

Read more