French investigators have described development of resistance to one of the last resort therapies used to treat extremely drug-resistant Pseudomonas aeruginosa. That resistance arose in a single patient over a scant 22 days. They subsequently identified the single nucleotide mutation in P. aeruginosa that caused the resistance.
Read moreA team has developed a new CRISPR genome-editing approach by combining two of the most important proteins in molecular biology — CRISPR-Cas9 and a reverse transcriptase — into a single machine.
Read moreThere are many indications that fasting promotes longevity. In recent years, much attention has been devoted to so-called caloric restriction mimetics (CMRs), substances that simulate the health-promoting effects of fasting without the need of life-style change. A study reports the identification of a novel candidate CRM. The substance may prove useful in the further research for the treatment of age-related diseases.
Read moreScientists are finding new ways to improve the use of the CRISPR enzyme Cas9 and reduce the chances of off-target mutations in laboratory mice, according to new results. The findings will help scientists contextualize a common concern related to gene editing and identify new strategies to improve its precision.
Read moreThe once-rare 'fabella' bone has made a dramatic resurgence in human knees, but who's likely to have a fabella or two — and why?
Read moreResearchers have identified a targeted therapy for adolescent patients with neuroblastoma, a deadly pediatric nerve cancer, who would otherwise have no treatment options, according to a new study.
Read moreResearchers have found that carriers of the most common genetic variant that causes cystic fibrosis experience some symptoms similar to those of people with cystic fibrosis. These findings were enabled by large-scale genomic data made available just a few years ago.
Read moreA new study links health insurance literacy with medical financial hardship as well as non-medical financial sacrifices among adult cancer survivors in the United States.
Read moreResearchers have discovered a circuit in rats that links cigarette smoking and the risk of developing type 2 diabetes, according to a new study.
Read moreResearchers clarify mechanisms that allow hard-to-treat cancers to develop, and have identified strategies that could lead to new therapies.
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