Breaking the stroma barrier: Study shows a new way to hit cancer with radiation

Chemotherapy and radiation therapy are commonly used to treat cancer, but are not always effective and can have toxic side effects. Researchers tested a new radiotherapy technique that sends alpha-emitting particles to stroma cells in pancreatic tumors. The method slowed tumor growth in mice with minimal side effects, pointing to a new potential treatment option in the future for patients with pancreatic cancer.

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'Instant liver, just add water'? Not quite, but a better way to grow multiple organs

Pluripotent stem cells can be used to make experimental models of organ systems, but current techniques often produce models that bear limited resemblance to true organs. Researchers developed an improved method to make a sophisticated three-dimensional organoid model of the liver, pancreas, and bile ducts. The model may help researchers understand how these organs form and how genetic mutations can lead to diseases in these organs.

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New insights into the structure and function of Cdc34, a target for cancer therapeutics

Researchers report they have obtained 3D structural snapshots of Cdc34 in action. Cdc34 is an enzyme important for cell cycle regulation and a target for therapeutic intervention in cancer. These structures, along with studies in human cells, have revealed key features of this enzyme important for its regulation of cell growth and activity. These unique features could present opportunities for rational design of novel cancer therapeutics.

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Digital breast tomosynthesis increases cancer detection over full-field mammography

A new article compares cancer detection rates (CDR) for screening digital breast tomosynthesis (DBT) versus full-field digital mammography (FFDM). Researchers found that DBT results in 'significantly increased CDR' — irrespective of tumor type, size, or grade of cancer.

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