Opioid Rx dosages drop with state law changes

The total amount of opioids dispensed per new opioid prescription decreased by 22% in Penn Medicine outpatient practices in New Jersey after the state passed a law limiting prescriptions to a five-day supply for new opioid prescriptions. Penn Medicine implemented an electronic health record (EMR) alert, or 'nudge,' to notify clinicians if that limit had been reached.

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Protective mediators can help heal injured tendon cells by attacking inflammation

Tendon tears, both to the rotator cuff and Achilles heel, are common injuries, especially in aged individuals. Painful and disabling, they can adversely impact quality of life. New approaches are required to help patients suffering from chronic tendon injuries. A novel study identified mediators that promote resolution of inflammation as potential new therapeutics to push chronically injured tendons down an inflammation-resolving pathway.

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Brain mechanisms have potential to block arthritis pain

Because pain is a complex condition, treating it efficiently continues to pose challenge for physicians. Past pain research typically has focused upon the spinal cord or the peripheral areas of the nervous system located outside the spinal cord and brain. However, a research team recently investigated how some mechanisms in the brain contribute to pain.

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New approach to pain treatment in diseases of the pancreas

One of the worst symptoms associated with inflammation or cancer of the pancreas is severe chronic pain. Pancreatic pain is difficult to treat, because many painkillers prove ineffective in pancreatic patients. In a recent study, medical researchers discovered the cause of this phenomenon for the first time: a particular neuroenzyme in the body is present in the nerves of the organ in high concentrations.

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New AI method may boost Crohn's disease insight and improve treatment

Scientists have developed a computer method that may help improve understanding and treatment of Crohn's disease, which causes inflammation of the digestive tract. The study used artificial intelligence to examine genetic signatures of Crohn's in 111 people. The method revealed previously undiscovered genes linked to the disease, and accurately predicted whether thousands of other people had the disease.

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