How hunger makes food tastier: A neural circuit in the hypothalamus

Using optogenetic and chemogenetic techniques, researchers have identified brain circuits underlying hunger-induced changes in the preferences for sweet and aversive tastes in mice. These circuits involved Agouti-related peptide-expressing neurons, which projected to glutamate neurons in the lateral hypothalamus. From there, glutamate neurons projecting to the lateral septum increased sweetness preferences, and glutamate neurons projecting to the lateral habenula decreased sensitivity to aversive tastes.

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The brain does not follow the head

The human brain is about three times the size of the brains of great apes. This has to do, among other things, with the evolution of novel brain structures that enabled complex behaviors such as language and tool production. A study by anthropologists now shows that changes in the brain occurred independent of evolutionary rearrangements of the braincase.

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