Uncovering the presynaptic distribution and profile of mitochondria
Scientists have provided unprecedented insight into the presynaptic distribution and profile of mitochondria in the developing and mature calyx of Held.
Read moreNervous System
Core symptom of schizophrenia reversed in adult mice
Researchers have restored normal working memory to a mouse model of schizophrenia, eliminating a core symptom of the disorder that, in people, has proven virtually impossible to treat.
Read moreNew method visualizes groups of neurons as they compute
Using a fluorescent probe that lights up when brain cells are electrically active, researchers found they can image the activity of many neurons at once, in mice brains. The technique could allow neuroscientists to analyze circuits within the brain and link them to specific behaviors.
Read moreScientists find gender-distinct circuit for depression
Depression affects women nearly twice as much as men, but unraveling the brain's blueprint that regulates this behavior, let alone identifying specific molecular differences between sexes, has proven difficult. Researchers, however, have found and flipped a switch in the brain, revealing a single circuit in mice that activates during stress and is controlled by testosterone.
Read moreFinding upends theory about the cerebellum's role in reading and dyslexia
New brain imaging research debunks a controversial theory about dyslexia that can impact how it is sometimes treated. The cerebellum, a brain structure traditionally considered to be involved in motor function, has been implicated in the reading disability, developmental dyslexia, however, this 'cerebellar deficit hypothesis' has always been controversial. The new research shows that the cerebellum is not engaged during reading in typical readers and does not differ in children who have dyslexia.
Read moreHow can ultrasonic brain stimulation cure brain diseases?
Scientists found a calcium channel expressed in astrocytes in the brain to be a highly sensitive target for LILFU-induced neuronal activity in the motor cortex, such as tail movement.
Read moreVoltage gated calcium channels 'read' electric patterns in embryos to create cartilage and bone
Scientists have revealed how the electrical patterns formed within an embryo initiate a cascade of molecular changes that culminate in the development of cartilage and bone. Prior studies have shown these electrical patterns appear like blueprints of the tissues and organs that eventually take shape as the embryo matures. The new study demonstrates that voltage gated calcium channels 'read' the electrical pattern, setting off the expression of genes that guide differentiation to mature cells.
Read moreSurprise contributor to multiple sclerosis
The discovery suggests new avenues for devising treatments and is a vital step toward finding a cure.
Read moreA timekeeper for siesta
External stimuli can rearrange the hierarchy of neuronal networks and influence behavior. This was demonstrated by scientists using the circadian clock of the fruit fly as an example.
Read moreStudy pinpoints Alzheimer's plaque emergence early and deep in the brain
By scanning whole brains of Alzheimer's model mice from an early age, researchers were able to precisely trace the terrible march of amyloid plaques from deep brain structures outward along specific circuits. They also showed that plaque density in a key region in humans scales with disease stage.
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