First targeted therapy for cholangiocarcinoma shows clinical benefit in phase III trial

New data have shown for the first time that targeted therapy can improve the outcome of patients diagnosed with advanced cholangiocarcinoma. Cholangiocarcinoma is a subtype of bile duct cancer with aggressive behavior and poor prognosis. Despite the low incidence, most patients die from the disease and therefore new effective therapies are urgently needed.

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African American children respond differently to asthma medications

African Americans suffer asthma more often and more severely than Caucasian patients. However, clinical trials that have shaped treatment guidelines have included few African Americans. A new report demonstrates a shortcoming of that history. Researchers report that African American children respond differently than African American adults and Caucasian adults and children to step-up therapies for inadequately controlled asthma.

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Researchers perform thousands of mutations to understand amyotrophic lateral sclerosis

Researchers have used a technique called high-throughput mutagenesis to study Amyotrophic Lateral Sclerosis (ALS), with unexpected results. Results showed that aggregation of TDP-43 is not harmful but actually protects cells, changing our understanding of ALS and opening the door to radically new therapeutic approaches.

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AAN recommends people 65+ be screened yearly for memory problems

To help physicians provide the highest quality patient-centered neurologic care, the American Academy of Neurology (AAN) is recommending physicians measure how frequently they complete annual assessments of people age 65 and older for thinking and memory problems.

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