Listening in to how proteins talk and learning their language

A research team has created a third approach to engineering proteins that uses deep learning to distill the fundamental features of proteins directly from their amino acid sequence without the need for additional information.

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Defining the centromere

Centromeres are the chromosomal domains at which the kinetochore, a protein complex required for the correct separation of chromosomes during mitosis and meiosis, is assembled. The incorporation of the histone variant CenH3 into centromeric nucleosomes is a prerequisite for the proper assembly and function of the kinetochore. A new study describes the chaperone protein NASPSIM3 and how it affects the depositioning of CenH3.

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Bioprinting: Living cells in a 3D printer

A high-resolution bioprinting process has been developed: Cells can now be embedded in a 3D matrix printed with micrometer precision — at a printing speed of one meter per second, orders of magnitude faster than previously possible. Tissue growth and the behavior of cells can be controlled and investigated particularly well by embedding the cells in a delicate 3D framework. This is achieved using so called 'bioprinting' techniques.

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Coffee bean extracts alleviate inflammation, insulin resistance in mouse cells

Food science and human nutrition researchers are interested in the potential of inflammation-fighting compounds found in the silverskin and husk of coffee beans, not only for their benefits in alleviating chronic disease, but also in adding value to would-be 'waste' products from the coffee processing industry.

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