New fluorescence method reveals signatures of individual microbes

Researchers have developed a new method that reveals the unique fluorescence patterns produced by individual cells in mixtures of bacteria, yeast and fungi. They combined confocal microscopy with micro-spectroscopy to determine the fluorescence signatures from different types of microbes. They trained machine learning systems to analyze the images and identify different individual cells and cell-types automatically, even those with very similar shapes and sizes.

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Engineered viruses could fight drug resistance

Biological engineers can program bacteriophages to kill different strains of E. coli by making mutations in the protein that the viruses use to bind to host cells. These engineered phages are less likely to provoke resistance in bacteria, and could help to overcome antibiotic resistance.

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Protozoans and pathogens make for an infectious mix

The new observation that strains of V. cholerae can be expelled into the environment after being ingested by protozoa, and that these bacteria are then primed for colonization and infection in humans, could help explain why cholera is so persistent in aquatic environments. The disease-causing bacteria are protected in the protozoan gut and ejected into the environment in membrane-bound expelled food vacuoles (EFVs).

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Babies have fewer respiratory infections if they have well-connected bacterial networks

Microscopic bacteria, which are present in all humans, cluster together and form communities in different parts of the body, such as the gut, lungs, nose and mouth. Now, for the first time, researchers have shown the extent to which these microbial communities are linked to each other across the body, and how these networks are associated with susceptibility to respiratory infections in babies.

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The flagellar hook: Making sense of bacterial motility

Researchers show how bacteria transmit motion from an inner motor to an outer tail through a flexible joint in the flagellum known as the hook. This finding could help in the fight against deadly bacterial infections. By better understanding how bacteria move, researchers may be able to improve disease prevention strategies.

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