Deep inside the brain: Unraveling the dense networks in the cerebral cortex

Mammalian brains, with their unmatched number of nerve cells and density of communication, are the most complex networks known. While methods to analyze neuronal networks sparsely have been available for decades, the dense mapping of neuronal circuits is a major scientific challenge. Researchers have now succeeded in the dense connectomic mapping of brain tissue from the cerebral cortex, and quantify the possible imprint of learning in the circuit.

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For better research results, let mice be mice

Animal models can serve as gateways for understanding many human communication disorders, but a new study suggests that the established practice of socially isolating mice for such purposes might actually make them poor research models for humans, and a simple shift to a more realistic social environment could greatly improve the utility of the future studies.

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The pectin is protectin': Study uncovers a plant barrier against toxic aluminum

Aluminum toxicity is a major contributor to poor crop growth, especially in regions with acidic soils. How aluminum enters at the growing root tips of plants is not well understood. Researchers have found that pectin, a chemical component of the plant cell wall, may play a key role as a barrier to prevent aluminum from entering rice plants. The study sheds light on how rice plants may resist aluminum toxicity.

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A possible gut-brain connection to 'chemo brain'

To test the possible relationship between the gut and chemo brain, a lab is examining chemo's effects on mice whose guts have been manipulated before treatment. One experiment involves feeding the mice antibiotics. The other relies on the universal practice among mice of eating their own and their roommates' feces.

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Reduced food intake in old mice can no longer improve health

Reduced food intake helps both animals and humans to improve health in old age and can prolong life. But when do you have to change your diet to achieve this benefit in old age? Scientists have now shown that mice only become healthier if they start food reduction early and eat less before entering old age. The scientists conclude that healthy behavior must be established earlier in life in order to improve health in old age and extend lifespan.

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Stressing cancer with spice

A new study reports how an experimental drug agent stops cancer cells from growing. A little over a decade ago, scientists first reported pentagamavumon-1 (PGV-1), an analogue of a molecule found in turmeric and that has been since discovered to have anti-cancer effects. In the new study, tests on cancer cells and animals reveal that these anti-cancer effects come from PGV-1 inhibiting a series of enzymes responsible for the metabolism of reactive oxygen species. This finding is expected to clarify how modifications to PGV-1 will lead to its use for cancer treatment.

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No defects found in reproductive ability of male mice returning from short stay in space

Male mice raised in space using specially developed cages were returned safely to Earth. The sperm production/fertilizing ability of the mice were normal and the reproduction ability of the offspring were not affected by their parents' stay in outer space. The findings on the effects of the environment in space on the male reproductive system will contribute to the accumulation of basic knowledge for humankind to expand the range of its activity to space.

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