A metabolic imbalance in some cancer patients following treatment with a checkpoint inhibitor drug, nivolumab, is associated with resistance to the immunotherapy agent and shorter survival, report scientists.
Read moreIn the presence of some disruptive elements, cancer cells are unable to replicate its DNA optimally. While known to be linked to the increase in genetic mutations, the exact mechanism at work remained unknown until now. By deciphering how replication stress induces the loss or gain of whole chromosomes in the daughters of cancer cells, researchers provide new knowledge that will ultimately lead to better diagnosis and possibly better treatment of cancer.
Read moreThe cells of our immune system constantly communicate with one another by exchanging complex protein molecules. A team has now revealed how dedicated cellular control proteins, referred to as chaperones, detect immature immune signaling proteins and prevent them from leaving the cell.
Read moreThe biological clock influences immune response efficacy. Indeed, CD8 T cells, which are essential to fight infections and cancers, function very differently according to the time of day.
Read moreFor the first time ever, researchers have mapped how bacterial cells trigger their defense against outside attacks. This could affect how diseases are fought in the future.
Read moreCells that become senescent irrevocably stop dividing under stress, spewing out a mix of inflammatory proteins that lead to chronic inflammation as more and more of the cells accumulate over time. Researchers have identified 44 specific senescence-associated proteins that are involved in blood clotting, marking the first time that cellular senescence has been associated with age-related blood clots.
Read moreIn experiments with mice, researchers have shown they can harness the power of iNKT cells to attack tumor cells and treat cancer. The new method suppressed the growth of multiple types of human tumors that had been transplanted into the animals.
Read moreA new platform brings together CRISPR genome editing with magnetic cell sorting to reveal new drug targets for cancer and regenerative medicine.
Read moreA big way chemotherapy works is by prompting cancer cells to commit suicide, and scientists have found a pathway the most common lung cancer walks to avoid death. Scientists have found a first step appears to be lung cancer cells expressing high levels of the molecule TIMP-1, classically considered a tumor inhibitor but at high levels already associated with a poor prognosis for patients.
Read moreResearchers have found that dogs can suffer from the same type of autoimmune encephalitis that people do. The finding could lead to better screening methods for diagnosis and possibly more effective treatments for canine encephalitis.
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