Immune therapy added to chemotherapy improves pathological complete response in patients with early triple negative breast cancer, according to new results from the KEYNOTE-522 trial. Interim results from the study, which is the first phase III trial of immunotherapy in early breast cancer, also indicated an improvement in event-free survival.
Read moreA new mechanism makes it possible to understand premature ageing in cells with asymmetrical cell division, as is the case with mother cells. Understanding this mechanism is useful for studying and, in the future, anticipating the development of ageing-related diseases, such as cancer and neurodegenerative processes.
Read moreScientists have taken a major step to address the challenge of engineer tissues organized like native tissues. They have demonstrated a new method to fabricate scaffolds presenting spatially organized cues to control cell behavior locally within one material.
Read moreNew research found that oncogene SET/TAF1, which was found to be a proto-oncogene of acute myeloid leukemia (AML), contributes to proper chromosome partitioning as a tension sensor. Additionally, abnormal SET protein disrupts tension sensor system at the centromere, leading to missegregation of the chromosomes and thereby cancer. These findings may lead to a discovery for a new kind of leukemia treatment.
Read moreA cluster of interacting proteins that are active in both human cancers and Tasmanian devil facial tumours, may give clues to how cancers evade the immune system, according to a new study.
Read moreThe Global Program to Eliminate Lymphatic Filariasis delivers mass drug administration to 500 million people each year, and adverse events are common following treatment. Now, researchers have reported that certain changes in gene expression are associated with these adverse events.
Read moreThe first cell atlas of the human kidney's immune system has been created after scientists mapped nearly 70,000 individual kidney cells from early life and adults. Researchers generated the atlas and used it to map immune cells in the kidney. This shows for the first time how the kidney's immune system develops during early life, and strengthens after birth and as we mature into adults, with implications for tackling kidney disease and transplant rejection.
Read moreA new imaging method follows young neurons in a developing embryo as they progress from a messy jumble of cells into a coordinated control center. The approach lets scientists track development and emerging cell function simultaneously across entire circuits.
Read moreScientists have discovered how temporal fluctuations in the levels of two transcription factors can push embryonic stems cells into becoming different cell types.
Read moreInvestigational drug with immunotherapy may provide new therapeutic opportunity for patients previously treated for kidney and lung cancer. Pegilodecakin with pembrolizumab and nivolumab shown to be safe in Phase 1B study.
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