Research maps key signaling pathways linking calcium entry and exit in activated T cells

Like entrance and exit doors on a building, a cell's outer surface has doors — channels, pumps, and transporters that selectively control what molecules enter or exit. In the immune system, T cells possess unique sets of 'doors', including ones that specialize in calcium ion movement. Now, researchers describe a unique mechanism for coordinating these calcium entrance and exit 'doors' on T cells that helps them carry out their jobs and ensure normal immune function.

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Mapping normal breast development to better understand cancer

Breast cancer is one of the most prevalent cancers, and some forms rank among the most difficult to treat. Its various types and involvement of many different cells makes targeting such tumors difficult. Now, researchers have used a state-of-the-art technology to profile each cell during normal breast development in order to understand what goes wrong in cancer.

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From sleeping cell to assassin — how immune cells work

Scientists have carried out one of the most comprehensive studies into how immune cells sense and respond to their environment to fight infection and destroy tumors. The research team said the results provide important insights into how immune responses might be manipulated for the treatment of autoimmune diseases and cancer.

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Scientists find timekeepers of gut's immune system

Shift work and jet lag disrupt not just sleep cycles, but feeding and digestive cycles as well. Such disruptions have been linked to risk of obesity, inflammatory bowel disease, infection, and other conditions. Now, researchers have identified an immune cell that helps set the daily rhythms of the gut. The findings open the door to new treatments for digestive ailments targeting such cells.

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Aggressive breast cancers store large amounts of energy, which enables it to spread

Researchers found that aggressive breast cancers store glycogen in very large amounts, offering an explanation of how cells can change their function to evade treatment, grow and spread. Targeting an enzyme involved in this process could potentially treat or prevent metastases.

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Scientist designs 'express courier service' for immune cells

A researcher who is currently doing his post-doctoral training at Stanford University, has successfully invented a novel transfection method to deliver DNA into immune cells with minimal stress on these cells. This new technique is expected to boost DNA-based cancer immunotherapy by significantly improving the process of generating high-quality genetically modified immune cells.

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