Algorithm personalizes which cancer mutations are best targets for immunotherapy

As tumor cells multiply, they often spawn tens of thousands of genetic mutations. Figuring out which ones are the most promising to target with immunotherapy is like finding a few needles in a haystack. Now a new model hand-picks those needles so they can be leveraged in more effective, customized cancer vaccines.

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Vaping-associated lung injury findings

A clinical perspective article reviews various imaging manifestations of electronic nicotine delivery systems such as e-cigarettes, vape pens, and hookah tanks. Despite the lack of a standardized case definition for vaping-associated lung injury, the radiologist may be the first person to prompt the clinical team to ask about relevant exposures like hypersensitivity pneumonitis, diffuse alveolar hemorrhage, acute eosinophilic pneumonia, organizing pneumonia, lipoid pneumonia, and giant cell interstitial pneumonia.

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'Wild idea' opens possible new frontier for preventing ovarian cancer

A laboratory study offers a new hypothesis about how ovarian cancer forms and suggests how it might be prevented. The study is the first to show that the natural stiffening of the ovaries called fibrosis occurs with age. It also suggests that the diabetes drug metformin may be able to halt this process.

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