How newly found tension sensor plays integral role in aligned chromosome partitioning

New research found that oncogene SET/TAF1, which was found to be a proto-oncogene of acute myeloid leukemia (AML), contributes to proper chromosome partitioning as a tension sensor. Additionally, abnormal SET protein disrupts tension sensor system at the centromere, leading to missegregation of the chromosomes and thereby cancer. These findings may lead to a discovery for a new kind of leukemia treatment.

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Pathway found for treatment-resistant lung cancer

A big way chemotherapy works is by prompting cancer cells to commit suicide, and scientists have found a pathway the most common lung cancer walks to avoid death. Scientists have found a first step appears to be lung cancer cells expressing high levels of the molecule TIMP-1, classically considered a tumor inhibitor but at high levels already associated with a poor prognosis for patients.

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Discovery of novel cancer signaling mechanism and design of new anticancer compound

Active mutations of a certain signaling receptor protein called KIT tyrosine kinase are found in several cancers, such as acute myeloid leukemia (AML). However, the different locations in the AML cells where KIT induces cancer-specific signaling remain unclear. Now, a group of scientists has aimed to answer this question by using a newly synthesized compound (along with other existing ones) that targets intracellular transport, which may offer an attractive strategy to combat cancer.

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