A blood factor involved in weight loss and aging

Aging can be delayed through lifestyle changes (physical exercise, restricting calorie intake, etc.). Researchers have elucidated the properties of a molecule in the blood – GDF11 – whose mechanisms were previously unknown. In a mouse model, they showed that this molecule could mimic the benefits of certain calorie restrictions – dietary regimens that have proven their efficacy in reducing cardiovascular disease, preventing cancer and increasing neurogenesis in the brain.

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How the brain dials up the volume to hear someone in a crowd

Our brains have a remarkable ability to pick out one voice from among many. Now, a team has uncovered the steps that take place in the brain to make this feat possible. Today's discovery helps to solve a long-standing scientific question as to how the brain's listening center can decode and amplify one voice over others. It also stands to spur development of hearing-aid technologies and brain-computer interfaces that more closely resemble the brain.

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Gene variants influence size of brainstem, other structures

Three-hundred researchers have identified 48 common genetic variants that are associated with the size of the brainstem and other subcortical structures deep within the brain. This is the first step toward understanding how to devise treatments for disorders affecting these structures.

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No link found between youth contact sports and cognitive, mental health problems

Adolescents who play contact sports, including football, are no more likely to experience cognitive impairment, depression or suicidal thoughts in early adulthood than their peers, suggests a new study of nearly 11,000 youth followed for 14 years.

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Novel nanoprobes show promise for optical monitoring of neural activity

Researchers have developed ultrasensitive nanoscale optical probes to monitor the bioelectric activity of neurons and other excitable cells. This novel readout technology could enable scientists to study how neural circuits function at an unprecedented scale by monitoring large numbers of individual neurons simultaneously. It could also lead to high-bandwidth brain-machine interfaces with dramatically enhanced precision and functionality.

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Cutting-edge neuroethics with ground-breaking neurotechnologies

Scientists are developing powerful new devices and technologies to monitor and regulate brain activity. To ensure NIH keeps pace with rapid technological development and help clinicians and researchers ethically fit these new tools into practice, a new article highlights potential issues around and offers recommendations about clinical research with both invasive and noninvasive neural devices.

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