Neurotoxocarosis (NT) occurs in humans when larvae of the Toxocara roundworm migrate into the central nervous system. That infection is accompanied by a complex molecular signaling cascade, including changes to anti-inflammatory lipid molecules, researchers now report.
Read moreChikungunya is an infectious disease caused by a mosquito-borne virus transmitted to humans. It is characterized by high fever and intense joint and muscle pain that can last for several months. The mechanisms of infection of human cells with the virus remain very poorly understood. Researchers have now identified a protein that is crucial in order for the virus to replicate within its target cells. This research opens up therapeutic avenues in the fight against chikungunya.
Read moreInfections that are treatable in healthy people can often be fatal in immunocompromised individuals (people with a weak immune system), and hence, they require specialized treatment. Eushearilide is already known to be active against a wide range of pathogenic fungi and yeasts, but its antibacterial properties have not been explored. Now, scientists have derived a new compound from eushearilide and demonstrated its antibacterial and antifungal properties. It can be used to treat lung infections, meningitis, and encephalitis.
Read moreResearchers have identified two key proteins, ASC and NLRP3, in the maintenance of the innate immune homeostasis in the airway. These proteins do so by a caspase-1-independent mechanism, suggesting that there may be multiple mechanisms involved in protection against microbial infections.
Read moreFungal bloodstream infections are responsible for the deaths of more than 10,000 people every year. New research shows that the death rate can be reduced by 20% if infectious disease specialists oversee care of such patients.
Read moreResearchers have identified a switch controlling HIV reproduction in immune cells which can eliminate dormant HIV reservoirs.
Read moreScientists have developed a new class of antibiotic drug candidates which has high potential to be developed into a new generation of antibiotics fighting against multi-drug resistant superbugs including methicillin-resistant Staphylococcus aureus (MRSA).
Read moreA new treatment method promises to speed up gene therapy research and could bring new, patient friendly cancer treatments to market faster.
Read moreOne of the WHO's 3 critical priority pathogens, Acinetobacter baumannii, for which new antibiotics are urgently needed is one step closer to being tackled, as researchers have made a breakthrough in understanding the enzymes that assemble the antibiotic enacyloxin.
Read moreScientists have discovered that a natural antioxidant commonly found in green tea can help eliminate antibiotic resistant bacteria.
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