How new loops in DNA packaging help us make diverse antibodies

It's long been known that our immune cells mix and match bits of genetic code to make new kinds of antibodies to fight newly encountered threats. But how these different gene segments come together has been a mystery. A study provides the answer, showing how the classic process of V(D)J recombination makes use of chromatin looping to gather the segments to be spliced.

Read more

Anesthetic drug sevoflurane improves sepsis outcomes, animal study reveals

Patients with sepsis often require surgery or imaging procedures under general anesthesia, yet there is no standard regimen for anesthetizing septic patients. Of volatile (inhaled) anesthetics, sevoflurane and isoflurane are the most commonly used drugs, despite their undetermined mechanisms of action. A novel study suggests that the type of drug used in general anesthesia could be critical to the survival of patients with sepsis.

Read more