Mapping international drug use through the world's largest wastewater study

A seven-year project monitoring illicit drug use in 37 countries via wastewater samples shows that cocaine use was skyrocketing in Europe in 2017 and Australia had a serious problem with methamphetamine.

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A rat's brain, on and off methamphetamine

Drug addiction is a vicious cycle of reward and withdrawal. Chronic users often relapse because of the unpleasant physical and psychological symptoms they experience when they stop taking the drug. Now, researchers report metabolic changes in the brains of rats during methamphetamine self-administration and withdrawal that could help identify biomarkers and treatments for addiction.

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Potential therapy to treat detrimental effects of marijuana

A new study using a preclinical animal model suggests that prenatal exposure to THC, the psychoactive component of cannabis, makes the brain's dopamine neurons (an integral component of the reward system) hyperactive and increases sensitivity to the behavioral effects of THC during pre-adolescence.

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Cannabis study reveals how CBD offsets the psychiatric side-effects of THC

Researchers have shown for the first time the molecular mechanisms at work that cause cannabidiol, or CBD, to block the psychiatric side-effects caused by tetrahydrocannabinol (THC), the main psychoactive chemical in cannabis.

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New fungus-derived antibiotic: Relief in sight for immunocompromised people

Infections that are treatable in healthy people can often be fatal in immunocompromised individuals (people with a weak immune system), and hence, they require specialized treatment. Eushearilide is already known to be active against a wide range of pathogenic fungi and yeasts, but its antibacterial properties have not been explored. Now, scientists have derived a new compound from eushearilide and demonstrated its antibacterial and antifungal properties. It can be used to treat lung infections, meningitis, and encephalitis.

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