Cellular senescence is associated with age-related blood clots

Cells that become senescent irrevocably stop dividing under stress, spewing out a mix of inflammatory proteins that lead to chronic inflammation as more and more of the cells accumulate over time. Researchers have identified 44 specific senescence-associated proteins that are involved in blood clotting, marking the first time that cellular senescence has been associated with age-related blood clots.

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Thinner shells for delivering gentler therapeutic bursts

Releasing drugs that are packaged into microcapsules requires a significant amount of force, and the resulting burst can cause damage to human tissues or cause blood clots. A new technique creates lopsided microcapsule 'shells' that can burst and release their cargo at much lower pressure, making them safer for use in the body.

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Better samples, better science: New study explores integrity of research specimens

Biological samples can be highly susceptible to changes over time, which often occur when they are removed from deep refrigeration. Degraded samples can produce spurious results in research. To address these concerns, scientists have designed a highly sensitive test that can be used to establish the integrity of blood plasma and serum, the most common biosamples used in medical research.

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New mechanism for dysfunctional insulin release identified

Researchers have identified a previously unknown mechanism that regulates release of insulin, a hormone that lowers blood glucose levels, from the beta cells of the pancreas. This mechanism is disrupted in type 2 diabetes. The scientists hope this finding will be used to develop new treatments against the disease.

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