Treating pulmonary embolism: How safe and effective are new devices?

A new scientific statement identifies the risks and benefits of novel interventional devices compared to anticoagulation alone in the treatment of patients with pulmonary embolism. Authors conclude there is little data — particularly, as it pertains to the treatment of patients with 'intermediate-risk PE' — that suggests these interventional approaches are more safe and effective than the use of anticoagulation alone.

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Ibrutinib linked to high blood pressure and other heart problems, study suggests

Over half of people prescribed the targeted blood cancer-fighting drug ibrutinib developed new or worsened high blood pressure within six months of starting the medication. The analysis is also the first to tie ibrutinib-related hypertension to a heightened risk of heart problems, particularly atrial fibrillation. Moreover, the association of ibrutinib with cardiovascular complications remained regardless of the prescribed dose.

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Protein associated with many diseases fully visualized for first time

For the first time, researchers have learned at the molecular level how the P2X7 protein receptor – which is associated with inflammation, coronary artery disease, cancer, multiple sclerosis and more – works. The findings could one day inspire new drugs to treat numerous medical conditions.

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First-time pregnancy complications linked to increased risk of hypertension later in life

Women who experience complications such as preterm births and preeclampsia during their first pregnancy are nearly twice more likely than women without complications to develop high blood pressure later in life — some as quickly as 3 years later, according to a new study of more than 4,000 women.

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Simulations characterize turbulence caused by common connection for dialysis

The complex interplay among the arteriovenous grafts, the vessels they connect, and the blood they transport has been difficult to simulate, but one new method provides a way. Researchers report simulations that reconstructed the fluid dynamics affected by the insertion of an AVG. They used a model that considered the ability of AVG tubes and blood vessels to deform and found much of the disrupted flow could be mitigated by this flexibility.

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Researchers discover new, treatable pathway known to cause hypertension in obese people

There's no question that as body weight increases, so too does blood pressure. Now, in a study of mice, researchers have revealed exactly which molecules are likely responsible for the link between obesity and blood pressure. Blocking one of these molecules — a signaling channel that's found in a tiny organ on the side of your neck — effectively lowers blood pressure in obese mice.

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Mystery underlying heart toxicity caused by diabetes drugs solved

For new diabetes medications, in which one drug aims to address the excess of lipids and glucose in the blood, the therapeutic benefits, while great, frequently are accompanied by dangerous toxic effects to the heart. Why and how these drugs cause heart dysfunction in diabetes patients has been unclear. Now, scientists show that certain diabetes drugs have a profound toxic effect on the generation and function of mitochondria.

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