Initiating breastfeeding in vulnerable infants

The benefits of breastfeeding for both mother and child are well-recognized, including for late preterm infants (LPI). But because LPI do not have fully developed brains, they may experience difficulties latching and/or sustaining a latch on the breast to have milk transfer occur. This means that these infants are at high risk for formula supplementation and/or discontinuation of breastfeeding.

Read more

Early humans evolved in ecosystems unlike any found today

To understand the environmental pressures that shaped human evolution, scientists must reconstruct the ecosystems in which they lived. Because putting together the puzzle of millions-of-years-old ecosystems is a difficult task, many studies draw analogies with present-day African ecosystems, such as the Serengeti. A new study calls into question such approaches and suggests that the vast majority of human evolution occurred in ecosystems unlike any found today.

Read more

Histone modifications are the influencers of zygotic genome awakening

Scientists have observed changes to the gene-regulating factors during zebrafish development and discovered that modifications to 'histone H3', one of the proteins around which DNA is bound, play an important role in 'zygotic genome activation' or transition of control of zebrafish embryonic development from maternal material to the zygote.

Read more

Large genome-wide association study illuminates genetic risk factors for gout

Researchers, using a method called genome-wide association study, have illuminated the genetic underpinnings of high serum urate, the blood condition that brings on gout. The study will inform efforts to develop screening tests for gout risk as well as potential new treatments.

Read more

Scientists find way to quantify how well cutting-edge microscopy technique works

Scientists provide a foundation for quantitatively determining how differences in viewing angles affect the resulting 3D structures of proteins, and could help other researchers determine the best setup for experiments to improve the imaging technique called cryo-EM.

Read more

Weak spot in pathogenic bacteria

Antibiotics are still the most important weapon for combatting bacterial infections. But medical science is running out of ''ammunition'' because of more and more frequently occurring resistances. Research teams have now elucidated the structure of the proteolytic complex ClpX-ClpP. This is a key to development of innovative antibiotics which target the degradation process of defective proteins in bacteria.

Read more

Scientists ID new targets to treat fibrosis, a feature of many chronic diseases

When it comes to repairing injured tissue, specialized cells in the body known as fibroblasts are called into action. Fibroblasts give rise to healing cells called myofibroblasts, which generally is good in the short term — but bad when myofibroblast activation gets out of hand. Now, researchers show how fibroblast activation and myofibroblast formation occurs, providing clues for how to target fibrosis — which impacts several chronic diseases.

Read more