New CRISPR genome editing system offers a wide range of versatility in human cells

A team has developed a new CRISPR genome-editing approach by combining two of the most important proteins in molecular biology — CRISPR-Cas9 and a reverse transcriptase — into a single machine.

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GAS7 protein allows cells to eat

Phagocytosis can be viewed as a primitive immune system used by all cells. When a pathogen is near the cell, the cell membrane will deform to engulf the pathogen and dispose of it. Researchers have found that a two-dimensional sheet formed by the protein GAS7 is critical for this process, identifying through crystallography and microscopy two key hydrophilic loops in the protein.

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Lifestyle is a threat to gut bacteria: Ötzi proves it, study shows


The evolution of dietary and hygienic habits in Western countries is associated with a decrease in the bacteria that help in digestion. These very bacteria were also found in the Iceman, who lived 5300 years ago, and are still present in non-Westernized populations in various parts of the world. The depletion of the microbiome may be associated with the increased prevalence, in Western countries, of complex conditions like allergies, autoimmune and gastrointestinal diseases, obesity.

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Parasite paralysis: A new way to fight schistosomiasis?

Scientists have isolated a natural chemical that acts as a potent kryptonite against parasitic worms that burrow through human skin and cause devastating health problems. Researchers now describe the successful characterization of this chemical, which could help in finding new ways to fight the neglected tropical disease schistosomiasis.

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