New factor in the development of childhood lymphoma

The immune system is highly complex and a detailed understanding of many underlying mechanisms is still lacking. Only the precise interaction of a variety of factors guarantees a reliable and correct immune response in a healthy body. Misregulated immune responses are a major cause of a variety of diseases, including cancer, autoimmunity, and immune deficiency.

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Drug delivery: Thermo-responsive protein hydrogel

Bio-engineering researchers have created a biocompatible, protein-based hydrogel that could serve as a drug delivery system durable enough to survive in the body for more than two weeks while providing sustained medication release. The research advances an area of biochemistry that is also critical to tissue engineering and regenerative medicine. Protein hydrogels are more biocompatible than synthetic ones and do not require potentially toxic chemical crosslinkers.

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Too much of a good thing: Overactive immune cells trigger inflammation

Scientists describe a previously unknown disorder of the immune system: in a distinct subset of immune cells from patients with primary immunodeficiency, cellular respiration is significantly increased. This cellular metabolic overactivity leads to inflammation.

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Starting HIV treatment in ERs may be key to ending HIV spread worldwide

Researchers say they have evidence that hospital emergency departments (EDs) worldwide may be key strategic settings for curbing the spread of HIV infections in hard-to-reach populations if the EDs jump-start treatment and case management as well as diagnosis of the disease.

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Sweet success of parasite survival could also be its downfall

Scientists have discovered how a parasite responsible for spreading a serious tropical disease protects itself from starvation once inside its human host. The findings provide a new understanding of the metabolism of the Leishmania parasite and this new knowledge could potentially be used in its eradication.

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