Potential target for cardiac fibrosis treatment

A research team has identified a potential target for treating heart failure related to fibrosis. The study looked at an epigenetic 'reader' protein known as BRD4, showing that it serves a central role in regulating the activation of cardiac fibroblasts. They also found that chemical inhibitors of BRD4 potently block cardiac fibroblast activation.

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Shorter people are at higher risk of type 2 diabetes, study shows


Short stature is associated with a higher risk of type 2 diabetes, according to a new study. Tall stature is associated with a lower risk, with each 10cm difference in height associated with a 41 percent decreased risk of diabetes in men and a 33 percent decreased risk in women.

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Defective cilia linked to heart valve birth defects

Bicuspid aortic valve (BAV), the most common heart valve birth defect, is associated with genetic variation in human primary cilia during heart valve development, report researchers. Crucial to cilia development is the exocyst, which shuttles cilia cargo to the cell membrane. Disrupting the exocyst impaired ciliogenesis and caused a spectrum of cardiac defects in zebrafish and BAV in mice.

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