Changes associated with Alzheimer's disease detectable in blood samples

Researchers have discovered new changes in blood samples associated with Alzheimer's disease. A new international study was conducted on disease-discordant Finnish twin pairs: one sibling suffering from Alzheimer's disease and the other being cognitively healthy. The researchers utilised the latest genome-wide methods to examine the twins' blood samples for any disease-related differences in epigenetic marks which are sensitive to changes in environmental factors. These differences between the siblings were discovered in multiple different genomic regions.

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Slower walkers have older brains and bodies at 45

The walking speed of 45-year-olds can be used as a marker of their aging brains and bodies. The evidence was there in neurocognitive testing these individuals took at age 3 to indicate who would become the slower walkers. At 45, slower walkers have 'accelerated aging' on a 19-measure scale devised by researchers, and their lungs, teeth and immune systems tended to be in worse shape than the people who walked faster.

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Deciphering the early stages of Parkinson's disease is a matter of time

Researchers haveidentified for the first time the initial steps of alpha-synuclein protein aggregates related to early onsets of hereditary Parkinson cases. The results may help the understanding of the early stages of the disease and how it develops over time.

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Scientists are decoding the genetic mechanisms of aging

Scientists describes the mechanisms by which longevity is regulated post-transcriptionally, or after a genetic blueprint has been transcribed from an organism's DNA. The identification of these mechanisms will serve as a road map for screening new, more specific drugs to prolong healthy lifespan. The laboratory focuses on research on regeneration and aging.

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Serum neurofilament is a discriminative biomarker between frontotemporal dementia and psychiatric disorders

Early symptoms of frontotemporal dementia are often confused with symptoms occurring in psychiatric disorders. Researchers show that serum neurofilament levels can be used as a diagnostic tool to differentiate between these conditions.

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