Treatment of metabolic dysfunction could be a potential therapy for Alzheimer's disease
A team of researchers has found evidence that metabolic dysfunction is a primary cause of Alzheimer's disease.
Read moreHealthy Aging
Failure of mitochondrial quality control causes heart disease
Mutations in the gene that encodes a protein called ANT cause a variety of conditions, such as heart disease, but the underlying mechanism of how these mutations trigger disease has been unclear. Researchers discovered that ANT is critical for a quality control process called mitophagy — which helps to ensure the integrity of the mitochondria network — and found that mutations that lead to a defective quality control system cause heart disease.
Read moreIn a first, scientists pinpoint neural activity's role in human longevity
Researchers discover that the activity of the nervous system might influence human longevity. Neural excitation linked to shorter life, while suppression of overactivity appears to extend life span. Protein REST, previously shown to protect aging brains from dementia and other diseases, emerges as a key player in molecular cascade related to aging. Findings suggest future avenues for intervention in diseases ranging from Alzheimer's to bipolar disorder.
Read moreOxygen in hyperbaric chamber provides relief after radiotherapy
Hyperbaric oxygen therapy (HBOT) can relieve self-reported symptoms and side-effects of radiotherapy against cancer in the pelvic region, a study shows. After 30-40 sessions in a hyperbaric chamber, many patients experienced reductions in bleeding, urinary incontinence, and pain alike.
Read moreBolivian forager-farmers known for amazing heart health are divided about what makes a good life
A small Bolivian society of indigenous forager-farmers, known for astonishingly healthy cardiovascular systems, is seeing a split in beliefs about what makes a good life. Some are holding more to tradition — family ties, hunting and forest medicine — but others are starting to favor material wealth, a new study finds.
Read moreFrailty: The rising global health burden for an aging society
Despite the evidence on risk factors for frailty, and the substantial progress that has been made in frailty awareness, the biological mechanisms underlying its development are still far from understood and translation from research to clinical practice remains a challenge. A new article provides an up-to-date clinical overview on preventing, identifying and managing frailty as well as its global impact and burden.
Read moreImproving research with more effective antibodies
A new study points to the need for better antibody validation, and outlines a process that other labs can use to make sure the antibodies they work with function properly.
Read moreNew DNA 'clock' could help measure development in young children
Scientists have developed a molecular 'clock' that could reshape how pediatricians measure and monitor childhood growth and potentially allow for an earlier diagnosis of life-altering development disorders.
Read moreProtein misfolding as a risk marker for Alzheimer's disease
In symptom-free individuals, the detection of misfolded amyloid-beta protein in the blood indicated a considerably higher risk of Alzheimer's disease — up to 14 years before a clinical diagnosis was made. Amyloid-beta folding proved to be superior to other risk markers evaluated.
Read morePTSD nearly doubles infection risk
A new study is the first to examine the relationship between post-traumatic stress disorder (PTSD) and dozens of infection types in a nationwide cohort. Researchers found that PTSD affects infection risks for men and women differently, having, for example, more of an effect on a woman's risk of urinary tract infection and a man's risk of skin infection.
Read more