Adult fly intestine could help understand intestinal regeneration

Intestinal epithelial cells (IECs) are exposed to diverse types of environmental stresses such as bacteria and toxins, but the mechanisms by which epithelial cells sense stress are not well understood. New research has found that Nox-ROS-ASK1-MKK3-p38 signaling in IECs integrates various stresses to facilitate intestinal regeneration.

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Engineered protein crystals make cells magnetic

If scientists could give living cells magnetic properties, they could perhaps manipulate cellular activities with external magnetic fields. But previous attempts to magnetize cells by producing iron-containing proteins inside them have resulted in only weak magnetic forces. Now, researchers have engineered genetically encoded protein crystals that can generate magnetic forces many times stronger than those already reported.

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Unravelling an alternative mechanism of airway mucosal immunity

Researchers have identified two key proteins, ASC and NLRP3, in the maintenance of the innate immune homeostasis in the airway. These proteins do so by a caspase-1-independent mechanism, suggesting that there may be multiple mechanisms involved in protection against microbial infections.

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How molecular footballs burst in an x-ray laser beam

An international research team has observed in real time how football molecules made of carbon atoms burst in the beam of an X-ray laser. The study shows the temporal course of the bursting process, which takes less than a trillionth of a second, and is important for the analysis of sensitive proteins and other biomolecules, which are also frequently studied using bright X-ray laser flashes.

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Capturing extreme close-ups of cellular gene expression

Scientists studying genetic transcription are gaining new insights into a process that is fundamental to all life. Transcription is the first step in gene expression, the process taking place within all living cells by which the DNA sequence of a gene is copied into RNA, which in turn (most generally speaking) serves as the template for assembling protein molecules, the basic building blocks of life.

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