Deformed Wing Virus (DWV), one of the leading causes of honey bee colony losses, is much more genetically diverse in the United States than previously thought. The diverse lineages of this virus are all equally bad for bees, and they make it more complicated to develop antiviral therapeutics, which could be the basis for developing a vaccine for the virus.
Read moreLaryngeal paralysis is a serious and sometimes deadly disease in some dog breeds that prevents proper opening of the larynx for breathing. Specialists in canine head and neck surgery and geneticists have identify a mutation responsible for laryngeal paralysis in Miniature Bull Terriers, enabling the development of a genetic test for the disease.
Read moreResearchers have identified a structural protein that is essential for the coordinated beating of millions of tiny cilia on the surface of comb jellies. When the protein was eliminated, the cilia began beating out of formation, stalling the locomotion of the jellies. These findings will help uncover how various organisms have adapted to life in different aquatic environments.
Read moreAluminum toxicity is a major contributor to poor crop growth, especially in regions with acidic soils. How aluminum enters at the growing root tips of plants is not well understood. Researchers have found that pectin, a chemical component of the plant cell wall, may play a key role as a barrier to prevent aluminum from entering rice plants. The study sheds light on how rice plants may resist aluminum toxicity.
Read moreResearchers report the discovery of a protein, P17/PERMIT, that is key to recycling aging and damaged mitochondria. Defective mitochondria are characteristic of a number of age-related diseases, including cancer and Alzheimer's. The MUSC team showed P17/PERMIT transports the machinery that produces ceramide, a molecule that signals old mitochondria for destruction, to the mitochondria. There, it can mass-produce ceramide at the location needed for mitochondrial regulation.
Read moreTadpoles that can typically regrow amputated tails or limbs lost their ability to regenerate after researchers blocked the expression of a newly identified gene that is one of the drivers for this regrowth. Furthermore, scientists hypothesize that the loss of appendage regeneration in warm-blooded animals might have been caused by the gain or loss of this gene, dubbed c-Answer, in an ancestor's genome during evolution.
Read moreNew research shows that lactate, an end product of metabolism, changes the function of an immune cell known as a macrophage, thereby rewiring it to behave differently.
Read moreNew research on an enzyme that is essential for photosynthesis and all life on earth has uncovered a key finding in its structure which reveals how light can interact with matter to make an essential pigment for life.
Read moreA new study reports how an experimental drug agent stops cancer cells from growing. A little over a decade ago, scientists first reported pentagamavumon-1 (PGV-1), an analogue of a molecule found in turmeric and that has been since discovered to have anti-cancer effects. In the new study, tests on cancer cells and animals reveal that these anti-cancer effects come from PGV-1 inhibiting a series of enzymes responsible for the metabolism of reactive oxygen species. This finding is expected to clarify how modifications to PGV-1 will lead to its use for cancer treatment.
Read moreThe Israeli Acute Paralysis Virus is a pathogen that affects honey bees and has been linked to Colony Collapse Disorder, a key factor in decimating the bee population. Researchers have now analyzed in detail how the virus hijacks the cellular protein production machinery and misuses it for its own purposes.
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