For better research results, let mice be mice

Animal models can serve as gateways for understanding many human communication disorders, but a new study suggests that the established practice of socially isolating mice for such purposes might actually make them poor research models for humans, and a simple shift to a more realistic social environment could greatly improve the utility of the future studies.

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A possible gut-brain connection to 'chemo brain'

To test the possible relationship between the gut and chemo brain, a lab is examining chemo's effects on mice whose guts have been manipulated before treatment. One experiment involves feeding the mice antibiotics. The other relies on the universal practice among mice of eating their own and their roommates' feces.

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Researchers quantify Cas9-caused off-target mutagenesis in mice

Scientists are finding new ways to improve the use of the CRISPR enzyme Cas9 and reduce the chances of off-target mutations in laboratory mice, according to new results. The findings will help scientists contextualize a common concern related to gene editing and identify new strategies to improve its precision.

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Acaí berry extracts fight malaria in mice

Despite humanity's best efforts to eradicate malaria, the disease struck more than 200 million people in 2017, according to the World Health Organization. Worse yet, the parasite that causes malaria is developing resistance to many antimalarial drugs, including the mainstay, chloroquine. Researchers are actively searching for new treatments, and now, a group have found that acaí berry extracts can reduce parasites in the blood and prolong the survival of infected mice.

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Engineered viruses could fight drug resistance

Biological engineers can program bacteriophages to kill different strains of E. coli by making mutations in the protein that the viruses use to bind to host cells. These engineered phages are less likely to provoke resistance in bacteria, and could help to overcome antibiotic resistance.

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