When blood vessels are overly permeable

In Germany alone there are around 400,000 patients who suffer from chronic inflammatory bowel diseases. For the first time, researchers have discovered that dysfunctions in blood vessels play a significant role in the development of such diseases. In experimental model systems, the progression of the disease slowed down significantly by eliminating these dysfunctions.

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New capsule can orally deliver drugs that usually have to be injected

MIT engineers designed a drug capsule that can carry insulin or other protein drugs and protect them from the harsh environment of the gastrointestinal tract. When the capsule reaches the small intestine, it breaks down to reveal dissolvable microneedles that attach to the intestinal wall and release drug for uptake into the bloodstream.

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Scientists find timekeepers of gut's immune system

Shift work and jet lag disrupt not just sleep cycles, but feeding and digestive cycles as well. Such disruptions have been linked to risk of obesity, inflammatory bowel disease, infection, and other conditions. Now, researchers have identified an immune cell that helps set the daily rhythms of the gut. The findings open the door to new treatments for digestive ailments targeting such cells.

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Gut bacteria 'fingerprint' predicts radiotherapy side effects

Taking a 'fingerprint' of the mix of bacteria in the gut can indicate how susceptible individual cancer patients are to gut damage as a result of radiotherapy for prostate and gynaecological cancers, a new study shows. Researchers showed that having a reduced diversity of gut bacteria was associated with an increased risk of both immediate and delayed damage to the gut following radiotherapy.

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