Researchers have used a technique called high-throughput mutagenesis to study Amyotrophic Lateral Sclerosis (ALS), with unexpected results. Results showed that aggregation of TDP-43 is not harmful but actually protects cells, changing our understanding of ALS and opening the door to radically new therapeutic approaches.
Read moreUNC researchers have created an injectable multi-drug delivery system that is removable, biodegradable and effective for up to a year in some cases. The author says the ability to administer multiple drugs with this implant is an important advancement in this research.
Read moreA research team has examined the interplay between genetics, cardiovascular disease and educational attainment in a major population study. Genetic variants which had been linked to educational attainment in other studies were observed in the subjects. The researchers found that these variants also had implications for a more health-conscious lifestyle and thus a lower risk of cardiovascular disease – in some cases regardless of the level of education.
Read moreResearchers have found changes in molecules in the blood that might be new markers of type 1 diabetes. New findings may help understand the early pathogenesis of the disease.
Read moreA new study details a possible solution for fine-tuning inflammation and cellular activity in cardiac recovery — thanks to an antibody initially developed for rheumatoid arthritis.
Read moreA new study suggests that the extinction of Neanderthals may be tied to persistent, life-long ear infections due to the structure of their Eustachian tubes, which are similar to those of human infants.
Read moreIn a proof-of-concept study, researchers have shown that exosomes harvested from human skin cells are more effective at repairing sun-damaged skin cells in mice than popular retinol or stem cell-based treatments currently in use. Additionally, the nanometer-sized exosomes can be delivered to the target cells via needle-free injections.
Read moreAround half of trials that supported new cancer drug approvals in Europe between 2014 and 2016 were judged to be at high risk of bias, which indicates that treatment effects might have been exaggerated, concludes a new study.
Read moreModifying a class of molecules originally developed to treat the skin disease psoriasis could lead to a new malaria drug that is effective against malaria parasites resistant to currently available drugs.
Read moreResearchers have discovered how a cancer-linked version of the protein mitoNEET can close voltage-dependent anion channels (VDAC), primary gateways in the outer surface of mitochondria. The researchers detail how mitoNEET regulates VDAC, and they show that the interactions between the two proteins could be disrupted by a drug that targets VDAC.
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