First prostate cancer therapy to target genes delays cancer progression

For the first time, prostate cancer has been treated based on the genetic makeup of the cancer, resulting in delayed disease progression, delayed time to pain progression, and potentially extending lives in patients with advanced, metastatic prostate cancer, reports a large phase 3 trial. This marks a significant advance for prostate cancer treatment, which has lagged behind other common cancers with regard to precision therapy, now the standard of care in breast, ovarian and lung cancers.

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AI system accurately detects key findings in chest X-rays of pneumonia patients within 10 seconds

From 20 minutes or more to 10 seconds. Researchers from Intermountain Healthcare and Stanford University say 10 seconds is about how quickly a new system they studied that utilizes artificial intelligence took to accurately identify key findings in chest X-rays of patients in the emergency department suspected of having pneumonia.

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First-time pregnancy complications linked to increased risk of hypertension later in life

Women who experience complications such as preterm births and preeclampsia during their first pregnancy are nearly twice more likely than women without complications to develop high blood pressure later in life — some as quickly as 3 years later, according to a new study of more than 4,000 women.

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Skin-cells-turned-to-heart-cells help unravel genetic underpinnings of cardiac function

A small genetic study identified a protein linked to many genetic variants that affect heart function. Researchers are expanding the model to other organ systems and at larger scales to create a broader understanding of genes and proteins involved.

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Simple cardiac risk score can predict problems with blood flow in the brain

The study shows that for those participants who do not have a history of heart disease or stroke that a simple cardiac risk score — a summary measure of factors such as blood pressure, diabetes, smoking, abdominal fat, and dietary factors — is associated with MRI-detected pre-clinical cerebrovascular disease like carotid artery plaque and silent strokes.

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First targeted therapy for cholangiocarcinoma shows clinical benefit in phase III trial

New data have shown for the first time that targeted therapy can improve the outcome of patients diagnosed with advanced cholangiocarcinoma. Cholangiocarcinoma is a subtype of bile duct cancer with aggressive behavior and poor prognosis. Despite the low incidence, most patients die from the disease and therefore new effective therapies are urgently needed.

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A new mechanism has been revealed which could lead to premature aging in mother cells

A new mechanism makes it possible to understand premature ageing in cells with asymmetrical cell division, as is the case with mother cells. Understanding this mechanism is useful for studying and, in the future, anticipating the development of ageing-related diseases, such as cancer and neurodegenerative processes.

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