Newly discovered protein is the permit to the powerhouse of cells

Researchers report the discovery of a protein, P17/PERMIT, that is key to recycling aging and damaged mitochondria. Defective mitochondria are characteristic of a number of age-related diseases, including cancer and Alzheimer's. The MUSC team showed P17/PERMIT transports the machinery that produces ceramide, a molecule that signals old mitochondria for destruction, to the mitochondria. There, it can mass-produce ceramide at the location needed for mitochondrial regulation.

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By cutting out one gene, researchers remove a tadpole's ability to regenerate

Tadpoles that can typically regrow amputated tails or limbs lost their ability to regenerate after researchers blocked the expression of a newly identified gene that is one of the drivers for this regrowth. Furthermore, scientists hypothesize that the loss of appendage regeneration in warm-blooded animals might have been caused by the gain or loss of this gene, dubbed c-Answer, in an ancestor's genome during evolution.

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Even the fetus has gut bacteria

A study in humans and mice demonstrated that a fetus has its own microbiome, or communities of bacteria living in the gut, which are known to play important roles in the immune system and metabolism. Researchers also confirmed that the fetal microbiome is transmitted from the mother.

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Special cells contribute to regenerate the heart in Zebrafish

It is already known that zebrafish can flexibly regenerate their hearts after injury. An international research group now shows that certain heart muscle cells play a central role in this process. The insights gained could be used to initiate a similar repair process in the human heart.

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Embryonic development: Earlier origin of neural crest cells

Neural crest cells have been thought to originate in the ectoderm, the outermost of the three germ layers formed in the earliest stages of embryonic development. But their capacity to form derivatives like bone and tooth-forming cells defies fundamental concepts in developmental and stem cell biology. A research team has found a solution to this mystery by demonstrating an earlier origin of the neural crest in chick embryos.

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Bullies may come and go, but the 'molecular memory' of being a target lingers

Life at the bottom of the social ladder may have long-term health effects that even upward mobility can't undo, according to new research in monkeys. A team studied 45 rhesus macaques. They found that monkeys who move up in the hierarchy still show the effects of their once-lowly status at the cellular level, even after they rise in rank.

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