Illumination of abnormal neuronal activities caused by myelin impairment

The neural circuit basis for motor learning tasks when myelination is impaired has been illuminated for the first time. Researchers also succeeded in compensating for the impaired motor learning process by pairing appropriate actions with brain photo-simulation to promote synchronization of neuronal activities. This could contribute to future treatments for neurological and psychiatric diseases in which white matter function is impaired.

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Beyond the 'replication crisis,' does research face an 'inference crisis'?

For the past decade, social scientists have been unpacking a 'replication crisis' that has revealed how findings of an alarming number of scientific studies are difficult or impossible to repeat. Efforts are underway to improve the reliability of findings, but cognitive psychology researchers say that not enough attention has been paid to the validity of theoretical inferences made from research findings.

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Serum neurofilament is a discriminative biomarker between frontotemporal dementia and psychiatric disorders

Early symptoms of frontotemporal dementia are often confused with symptoms occurring in psychiatric disorders. Researchers show that serum neurofilament levels can be used as a diagnostic tool to differentiate between these conditions.

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New diagnostic criteria may enable earlier detection of cognitive impairment in women

Study finds when verbal memory test cut-offs were tailored to patient sex, more female patients and fewer male patients were considered to have amnesic mild cognitive impairment. This could change the way aMCI diagnoses are determined and make it easier to catch the condition in its early stages.

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Targeting certain rogue T cells prevents and reverses multiple sclerosis in mice

Multiple sclerosis, an autoimmune disorder, is known to be driven by 'helper' T cells, white blood cells that mount an inflammatory attack on the brain and spinal cord. A new study pinpoints the specific subgroup of helper T cells that cause MS, as well as a protein on their surface, called CXCR6, that marks them. An antibody targeting CXCR6 both prevented and reversed MS in a mouse model, the researchers report.

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Study pinpoints Alzheimer's plaque emergence early and deep in the brain

By scanning whole brains of Alzheimer's model mice from an early age, researchers were able to precisely trace the terrible march of amyloid plaques from deep brain structures outward along specific circuits. They also showed that plaque density in a key region in humans scales with disease stage.

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Chair yoga more effective than music therapy in older adults with advanced dementia

Researchers assessed the ability of older adults with advanced dementia to participate in non-pharmacological interventions and compared chair yoga with chair-based exercise and music therapy. Results showed that participants with moderate-to-severe dementia could safely adhere to non-pharmacological interventions; more than 97 percent fully engaged in each session. The chair yoga group reported a higher quality of life score, including physical condition, mood, functional abilities, interpersonal relationships, and ability to participate in meaningful activities.

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