Rare diseases represent a global problem. Until now, the lack of data made it difficult to estimate their prevalence. The Orphanet database, which contains the largest amount of epidemiological data on these diseases taken from the scientific literature, has made it possible to obtain a global estimate.
Read moreScientists have made an important discovery in understanding the role a particular protein plays to impair memory in Alzheimer's disease, which could lead to more effective treatment in future.
Read moreTendon tears, both to the rotator cuff and Achilles heel, are common injuries, especially in aged individuals. Painful and disabling, they can adversely impact quality of life. New approaches are required to help patients suffering from chronic tendon injuries. A novel study identified mediators that promote resolution of inflammation as potential new therapeutics to push chronically injured tendons down an inflammation-resolving pathway.
Read moreIn Germany alone there are around 400,000 patients who suffer from chronic inflammatory bowel diseases. For the first time, researchers have discovered that dysfunctions in blood vessels play a significant role in the development of such diseases. In experimental model systems, the progression of the disease slowed down significantly by eliminating these dysfunctions.
Read moreScientists have developed a computer method that may help improve understanding and treatment of Crohn's disease, which causes inflammation of the digestive tract. The study used artificial intelligence to examine genetic signatures of Crohn's in 111 people. The method revealed previously undiscovered genes linked to the disease, and accurately predicted whether thousands of other people had the disease.
Read moreAdolescent acne does not always result in a pathological condition; rather, it may be a natural, transient inflammatory state occurring when the maturing facial skin is exposed to new microbes and enhanced production of an oily substance called sebum. Researchers argue that their novel framework suggests that the development of new treatments should focus on promoting mechanisms that restore homeostasis between facial skin and its microbial and chemical milieu.
Read moreThe cells of our immune system constantly communicate with one another by exchanging complex protein molecules. A team has now revealed how dedicated cellular control proteins, referred to as chaperones, detect immature immune signaling proteins and prevent them from leaving the cell.
Read moreBecause researchers demonstrated for the first time that a strong association between obesity and chronic diarrhea is not driven by diet or physical activity, the findings could have important implications for how physicians might approach and treat symptoms of diarrhea in patients with obesity differently.
Read moreA simple arthritis drug could be an effective, low cost solution to treat patients with blood cancers such as polycythemia vera (PV) and essential thrombocythemia (ET), a breakthrough study has shown.
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