Scientists have developed a new and more accurate method to identify the molecular signs of cancer likely to be presented to helper T cells, which stimulate and orchestrate the immune response to tumors and infectious agents.
Read moreWithout fat, nothing works in the body: These substances serve as energy suppliers and important building blocks — including for the envelopes of living cells. Numerous diseases are related to disorders in the fat metabolism, such as obesity or cancer. Researchers are now demonstrating how the fat metabolism can be monitored down to the individual liver cell of a mouse with the greatest sensitivity.
Read moreAs tumor cells multiply, they often spawn tens of thousands of genetic mutations. Figuring out which ones are the most promising to target with immunotherapy is like finding a few needles in a haystack. Now a new model hand-picks those needles so they can be leveraged in more effective, customized cancer vaccines.
Read moreUsing virtual, cloud-based, interconnected computing techniques applied to 51,000 variables, researchers reduced the time needed to assess a cancer patient's tumor profile and suitability for clinical trials from 14 to 4 days. This method also increased two-fold, over a four-year period, the number of cases that could be assessed compared to conventional methods.
Read moreA research group has discovered a novel cancer-driving mutation in the vast non-coding regions of the human cancer genome, also known as the 'dark matter' of human cancer DNA.
Read moreA new, multicenter study has determined how a single mutation in splicing factor 3b subunit 1 (SF3B1), the most frequently mutated splicing factor gene, drives the formation of many cancers.
Read moreA laboratory study offers a new hypothesis about how ovarian cancer forms and suggests how it might be prevented. The study is the first to show that the natural stiffening of the ovaries called fibrosis occurs with age. It also suggests that the diabetes drug metformin may be able to halt this process.
Read moreResearchers have shown the potential use of small molecule inhibitors to treat advanced liver cancer.
Read moreA research team reports that combining a type of radiation therapy with immunotherapy not only cures pancreatic cancer in mice, but appears to reprogram the immune system to create an 'immune memory' in the same way that a vaccine keeps the flu away. The result is that the combination treatment also destroyed pancreatic cells that had spread to the liver, a common site for metastatic disease.
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