Breaking the stroma barrier: Study shows a new way to hit cancer with radiation

Chemotherapy and radiation therapy are commonly used to treat cancer, but are not always effective and can have toxic side effects. Researchers tested a new radiotherapy technique that sends alpha-emitting particles to stroma cells in pancreatic tumors. The method slowed tumor growth in mice with minimal side effects, pointing to a new potential treatment option in the future for patients with pancreatic cancer.

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New insights into the structure and function of Cdc34, a target for cancer therapeutics

Researchers report they have obtained 3D structural snapshots of Cdc34 in action. Cdc34 is an enzyme important for cell cycle regulation and a target for therapeutic intervention in cancer. These structures, along with studies in human cells, have revealed key features of this enzyme important for its regulation of cell growth and activity. These unique features could present opportunities for rational design of novel cancer therapeutics.

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Digital breast tomosynthesis increases cancer detection over full-field mammography

A new article compares cancer detection rates (CDR) for screening digital breast tomosynthesis (DBT) versus full-field digital mammography (FFDM). Researchers found that DBT results in 'significantly increased CDR' — irrespective of tumor type, size, or grade of cancer.

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Inactive receptor renders cancer immunotherapies ineffective

The aim of immunotherapies is to enable the immune system once again to fight cancer on its own. Drugs known as checkpoint inhibitors are already in clinical use for this purpose. However, they are only effective in about one third of patients. Based on analysis of human tissue samples, a team has now discovered one reason why this is so: an inactive receptor in cancer cells prevents the drugs from reactivating the immune system.

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