A research team has identified a potential target for treating heart failure related to fibrosis. The study looked at an epigenetic 'reader' protein known as BRD4, showing that it serves a central role in regulating the activation of cardiac fibroblasts. They also found that chemical inhibitors of BRD4 potently block cardiac fibroblast activation.
Read moreWhen it comes to boosting mental health among older Chinese, it might be as simple as a game of mahjong, according to a new study.
Read moreA computer generated-simulation allowed researchers to see how a toxin produced by algal blooms in saltwater might cause Amyotrophic Lateral Sclerosis (ALS).
Read moreScientists appear to have solved a decades-long mystery regarding the precise biochemical pathway leading to a fatal genetic disorder in children that results in seizures, developmental regression and death, usually around age 3. Studying a mouse model with the same human illness — called Krabbe disease — the researchers also identified a possible therapeutic strategy.
Read moreScientists reported on the prevalence of multiple agents capable of causing human disease that are present in three species of ticks in Long Island.
Read moreBicuspid aortic valve (BAV), the most common heart valve birth defect, is associated with genetic variation in human primary cilia during heart valve development, report researchers. Crucial to cilia development is the exocyst, which shuttles cilia cargo to the cell membrane. Disrupting the exocyst impaired ciliogenesis and caused a spectrum of cardiac defects in zebrafish and BAV in mice.
Read moreNew research shows just how important positive childhood experiences are for long-term health, especially for those who experience significant adversity as a child. Studies over the past 20 years have found a correlation between adverse childhood events (such as death or divorce) and worse health outcomes later in life. A new study discovers that positive childhood experiences, like having good neighbors, or a teacher you trust, have the potential to negate harmful health effects caused by adverse childhood experiences.
Read moreResearchers say they have evidence that hospital emergency departments (EDs) worldwide may be key strategic settings for curbing the spread of HIV infections in hard-to-reach populations if the EDs jump-start treatment and case management as well as diagnosis of the disease.
Read moreNew research shows that specialist analysis of the lens in the eye can predict patients with type 2 diabetes and impaired glucose tolerance (IGT) (also known as prediabetes, a condition that often leads to full blown of type 2 diabetes).
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