Changes associated with Alzheimer's disease detectable in blood samples

Researchers have discovered new changes in blood samples associated with Alzheimer's disease. A new international study was conducted on disease-discordant Finnish twin pairs: one sibling suffering from Alzheimer's disease and the other being cognitively healthy. The researchers utilised the latest genome-wide methods to examine the twins' blood samples for any disease-related differences in epigenetic marks which are sensitive to changes in environmental factors. These differences between the siblings were discovered in multiple different genomic regions.

Read more

Repeated febrile convulsions linked to epilepsy and psychiatric disorders

The risk of febrile convulsions increases with the child's fever, and children who suffer from repeated febrile convulsions during their first year of life have an increased risk of developing epilepsy and psychiatric disorders later in life. This is shown by a comprehensive register-based study. In the study, almost 76,000 Danish children who have been suffering from febrile convulsions have been followed for more than 30 years.

Read more

New genetic-based epilepsy risk scores

An international team of researchers has developed new genetic-based epilepsy risk scores which may lay the foundation for a more personalized method of epilepsy diagnosis and treatment. This analysis is the largest study of epilepsy genetics to date, as well as the largest study of epilepsy using human samples.

Read more

New test diagnoses Lyme disease within 15 minutes

Current testing for Lyme disease, called the standard 2-tiered approach or the STT, involves running two complex assays (ELISA and western blot) to detect antibodies against the bacterium, and requires experienced personnel in a lab, and a few hours to carry out and interpret. Biomedical engineers have developed a rapid microfluidic test that can detect Lyme disease with similar performance as the STT in a much shorter time — 15 minutes.

Read more

Rare sleep disorder common among veterans with PTSD

Military veterans with post-traumatic stress disorder or concussion suffer from a thrashing form of sleep behavior at a rate that is far higher than the general population, according to a new study. Researchers next want to probe whether the sleep disorder might provide an early signal of the development of neurodegenerative conditions such as Parkinson's disease.

Read more

Deciphering the early stages of Parkinson's disease is a matter of time

Researchers haveidentified for the first time the initial steps of alpha-synuclein protein aggregates related to early onsets of hereditary Parkinson cases. The results may help the understanding of the early stages of the disease and how it develops over time.

Read more