How newly found tension sensor plays integral role in aligned chromosome partitioning

New research found that oncogene SET/TAF1, which was found to be a proto-oncogene of acute myeloid leukemia (AML), contributes to proper chromosome partitioning as a tension sensor. Additionally, abnormal SET protein disrupts tension sensor system at the centromere, leading to missegregation of the chromosomes and thereby cancer. These findings may lead to a discovery for a new kind of leukemia treatment.

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Investigational drug with immunotherapy may provide new therapeutic opportunity for patients previously treated for kidney and lung cancer

Investigational drug with immunotherapy may provide new therapeutic opportunity for patients previously treated for kidney and lung cancer. Pegilodecakin with pembrolizumab and nivolumab shown to be safe in Phase 1B study.

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A protein essential for chikungunya virus replication identified

Chikungunya is an infectious disease caused by a mosquito-borne virus transmitted to humans. It is characterized by high fever and intense joint and muscle pain that can last for several months. The mechanisms of infection of human cells with the virus remain very poorly understood. Researchers have now identified a protein that is crucial in order for the virus to replicate within its target cells. This research opens up therapeutic avenues in the fight against chikungunya.

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