New diagnostic method finds aggressive tumors
Researchers have developed a new cheap method that can identify highly heterogeneous tumors that tend to be very aggressive, and therefore need to be treated more aggressively.
Read moreBreast Cancer
New insights into the structure and function of Cdc34, a target for cancer therapeutics
Researchers report they have obtained 3D structural snapshots of Cdc34 in action. Cdc34 is an enzyme important for cell cycle regulation and a target for therapeutic intervention in cancer. These structures, along with studies in human cells, have revealed key features of this enzyme important for its regulation of cell growth and activity. These unique features could present opportunities for rational design of novel cancer therapeutics.
Read moreDigital breast tomosynthesis increases cancer detection over full-field mammography
A new article compares cancer detection rates (CDR) for screening digital breast tomosynthesis (DBT) versus full-field digital mammography (FFDM). Researchers found that DBT results in 'significantly increased CDR' — irrespective of tumor type, size, or grade of cancer.
Read moreExercise guidelines for cancer survivors
For the rising number of cancer survivors worldwide, there's growing evidence that exercise is an important part of recovery. But how much, and what type of exercise, is needed?
Read moreBeyond Mutation: Cause of drug resistance in a type of intestinal tumors
Researchers clarify mechanisms that allow hard-to-treat cancers to develop, and have identified strategies that could lead to new therapies.
Read moreProgress in global cancer fight is not only possible, but achievable
The Cancer Atlas, 3rd edition, a comprehensive global overview of cancer around the globe, concludes that progress in the fight against cancer is not only possible, but achievable.
Read moreAcceptance and commitment therapy may ease fear of recurrence in cancer survivors
Researchers report that Acceptance and Commitment Therapy (ACT) shows significant promise for treating fear of cancer recurrence in women who have survived breast cancer. Fear that cancer may come back or progress is especially common in breast cancer survivors, with up to 70% reporting that the fear affects their daily life.
Read moreInactive receptor renders cancer immunotherapies ineffective
The aim of immunotherapies is to enable the immune system once again to fight cancer on its own. Drugs known as checkpoint inhibitors are already in clinical use for this purpose. However, they are only effective in about one third of patients. Based on analysis of human tissue samples, a team has now discovered one reason why this is so: an inactive receptor in cancer cells prevents the drugs from reactivating the immune system.
Read moreDNA fracturing rewires gene control in cancer
A multi-institutional team has brought attention to genomic structural variation as a previously unappreciated mechanism involved in altering DNA methylation, a form of gene control, in human cancers.
Read moreScientists help immune system find hidden cancer cells
Cancer cells are masters at avoiding detection, but a new system can make them stand out from the crowd and help the immune system spot and eliminate tumors that other forms of immunotherapies might miss.
Read more