More efficient drug delivery within the brain by utilizing LAT1
According to a new study the distribution of drug molecules within the brain can be improved by utilizing LAT1, which is expressed highly in the brain.
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Potential therapeutic target for prostate cancers with PTEN mutation
PTEN, a tumor suppressor gene mutated in about 20% of prostate cancers, relies on another gene, ARID4B, to function.
Read moreEngineered killer T cells could provide long-lasting immunity against cancer
In experiments with mice, researchers have shown they can harness the power of iNKT cells to attack tumor cells and treat cancer. The new method suppressed the growth of multiple types of human tumors that had been transplanted into the animals.
Read morePathway found for treatment-resistant lung cancer
A big way chemotherapy works is by prompting cancer cells to commit suicide, and scientists have found a pathway the most common lung cancer walks to avoid death. Scientists have found a first step appears to be lung cancer cells expressing high levels of the molecule TIMP-1, classically considered a tumor inhibitor but at high levels already associated with a poor prognosis for patients.
Read more'Push-pull' dynamic in brain network is key to stopping seizures
Researchers have discovered that the spreading of seizures through the brain can be suppressed depending on the amount of pressure within the brain, an important discovery that may revolutionize the treatment of drug-resistant epilepsy.
Read moreDiscovery of novel cancer signaling mechanism and design of new anticancer compound
Active mutations of a certain signaling receptor protein called KIT tyrosine kinase are found in several cancers, such as acute myeloid leukemia (AML). However, the different locations in the AML cells where KIT induces cancer-specific signaling remain unclear. Now, a group of scientists has aimed to answer this question by using a newly synthesized compound (along with other existing ones) that targets intracellular transport, which may offer an attractive strategy to combat cancer.
Read moreCompound extends survival in mice with certain pediatric brain tumors
Versions of an antibiotic drug called DON first isolated from soil bacteria more than 60 years ago have shown promising signs of extending survival in mice models of especially lethal pediatric brain tumors marked by the high expression of a cancer-causing gene known as the MYC oncogene.
Read moreLeukemia drug shows promise for treating a childhood brain cancer
Researchers describe a new use of leukemia drug, nilotinib, to treat a subtype of medulloblastoma, a deadly pediatric brain cancer.
Read moreNovel regulator of mitochondrial cell death reveals a promising target for cancer therapy
Researchers have described the role of mitochondrial fission factor (MFF) in controlling survival of cancer cells, suggesting the protein could represent a promising therapeutic target.
Read moreNew mechanism for dysfunctional insulin release identified
Researchers have identified a previously unknown mechanism that regulates release of insulin, a hormone that lowers blood glucose levels, from the beta cells of the pancreas. This mechanism is disrupted in type 2 diabetes. The scientists hope this finding will be used to develop new treatments against the disease.
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